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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Related Experiment Videos

Physiology of skin aging.

L Robert1, J Labat-Robert, A-M Robert

  • 1Laboratoire de recherche ophtalmologique, université Paris-5, Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France. lrobert5@wanadoo.fr

Pathologie-Biologie
|December 3, 2008
PubMed
Summary
This summary is machine-generated.

Skin aging involves cellular and extracellular matrix changes, primarily at the post-genetic level. Fucose- and rhamnose-rich polysaccharides show potential in counteracting these aging mechanisms.

Related Experiment Videos

Area of Science:

  • Dermatology and cellular biology.
  • Focus on skin aging mechanisms.

Background:

  • Skin aging affects cellular and extracellular matrix components.
  • Age-dependent skin modifications are a key research area.
  • Mechanisms of skin aging are largely post-genetic.

Purpose of the Study:

  • To review cellular and extracellular matrix aspects of skin aging.
  • To explore the role of specific polysaccharides in counteracting skin aging.

Main Methods:

  • Review of epigenetic and post-translational mechanisms of skin aging.
  • Investigation of fucose- and rhamnose-rich oligo- and polysaccharides (FROP and RROP).

Main Results:

  • Skin aging involves complex post-genetic modifications.
  • FROP and RROP demonstrate capacity to counteract aging mechanisms.

Conclusions:

  • Understanding post-genetic mechanisms is crucial for skin aging research.
  • FROP and RROP represent a promising avenue for anti-aging interventions.