Related Experiment Video
Updated: Jun 27, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
A splenial lesion with transiently reduced diffusion in clinically mild encephalitis is not always reversible: A case
Yuji Hashimoto1, Jun-ichi Takanashi, Keiko Kaiho
1Department of Pediatrics and Radiology, Teikyo University Chiba Medical Center, Chiba, Japan. sdgcr596@ybb.ne.jp
Abstract:
The MR imaging finding of a reversible splenial lesion with transiently reduced diffusion has been reported in patients with clinically mild encephalitis/encephalopathy, leading to a new clinical-radiological syndrome, clinically mild encephalitis/encephalopathy with a reversible splenial lesion. We recently experienced a 3-year-old boy with clinically mild encephalitis with a splenial lesion exhibiting transient reduced diffusion on admission. He recovered completely with no particular treatment within 2 weeks. Though the splenial lesion decreased in size, it was detected for over 5 months in T2-weighted imaging. It is suggested that a splenial lesion with transiently reduced diffusion in clinically mild encephalitis/encephalopathy is not always reversible, and could result in gliosis.
Related Concept Videos
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Hepatic Encephalopathy
Ischemic Stroke ll: Pathophysiology
Brain Abscess l: Introduction
Cerebral Edema ll: Pathophysiology

