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[Lysine and human nutrition].

L Cynober1

  • 1Hôpital Saint-Antoine, Laboratoire de Biochimie A, Paris.

Annales De Biologie Clinique
|January 1, 1991
PubMed
Summary

Lysine is an essential amino acid with debated intake levels. Excessive lysine may be harmful, potentially causing kidney damage and atherosclerosis.

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Clinical nutrition (Edinburgh, Scotland)·2016

Area of Science:

  • Nutrition Science
  • Biochemistry
  • Metabolism

Context:

  • Lysine is an essential amino acid, vital for human health but not synthesized by the body.
  • Recommended daily intake of lysine has been a subject of ongoing scientific debate and revision.
  • Current parenteral nutrition guidelines for lysine intake vary, with higher amounts for infants.

Purpose:

  • To review and analyze the recommended daily intake of lysine.
  • To evaluate the metabolic implications of lysine supply in various clinical conditions.
  • To assess the potential adverse effects of excessive lysine intake.

Summary:

  • Lysine intake recommendations have evolved from nitrogen balance studies to isotope-based data.
  • Parenteral nutrition typically supplies lysine between 0.39-0.55 g/g nitrogen, with exceptions for infant formulas.
  • Evidence suggests current lysine supplies may be excessive, particularly in pathological states.
  • Excessive lysine can be nephrotoxic in renal failure patients and potentially atherogenic in spontaneous nutrition.

Impact:

  • Re-evaluation of lysine dosage in parenteral nutrition may be warranted.
  • Clinical guidelines for lysine supplementation in malnutrition and renal failure require careful consideration.
  • Understanding lysine's role in atherosclerosis could inform dietary recommendations.
  • This research highlights the importance of precise essential amino acid management in clinical nutrition.

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