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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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Updated: Jun 27, 2026

A Mouse Model of in Utero Transplantation
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Published on: January 27, 2011

Fetal microchimerism and cancer.

Janet A Sawicki1

  • 1Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA. sawickij@mlhs.org

Cancer Research
|December 3, 2008
PubMed
Summary

Fetal microchimerism, the presence of fetal stem cells in mothers, may contribute to diseases like cancer. Research into this phenomenon offers new insights into women's cancers, such as breast, ovarian, and lung cancers.

Area of Science:

  • Reproductive biology
  • Immunology
  • Oncology

Background:

  • Fetal microchimerism involves the persistence of fetal stem cells with multilineage potential in pregnant women.
  • This phenomenon is increasingly recognized for its potential role in various diseases.

Purpose of the Study:

  • To explore the implications of fetal microchimerism in the context of human diseases.
  • To investigate the potential link between fetal microchimerism and the development of cancers in women.

Main Methods:

  • Review of existing literature on fetal microchimerism.
  • Analysis of studies implicating fetal microchimerism in autoimmune diseases, wound healing, and cancer.
  • Examination of the relevance to specific cancers in women.

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07:51

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Murine Fetal Echocardiography
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Published on: February 15, 2013

Main Results:

  • Fetal microchimerism has been associated with autoimmune diseases and wound healing.
  • Evidence suggests a potential role for fetal microchimerism in the pathogenesis of certain cancers.
  • The phenomenon may offer a novel perspective on breast, ovarian, and lung cancers in women.

Conclusions:

  • Fetal microchimerism is a significant biological phenomenon with potential health implications.
  • Further research into fetal microchimerism could lead to new understandings and therapeutic strategies for women's cancers.