Significant association between neutrophil aggregation in aspirated thrombus and myocardial damage in patients with

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Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy
06:38

Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy

Published on: September 26, 2025

Kentaro Arakawa1, Satoshi Yasuda, Hiroyuki Hao

  • 1Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 3, 2008
PubMed

Insights

High neutrophil density in blood clots from acute myocardial infarction (AMI) patients correlates with worse heart outcomes. This highlights the link between inflammation and thrombosis in AMI.

Area of Science:

  • Cardiology
  • Hematology
  • Pathophysiology

Background:

  • Investigating the link between myocardial damage and platelet-neutrophil aggregation in acute myocardial infarction (AMI).
  • Understanding the role of inflammatory cells in the pathogenesis of AMI.

Purpose of the Study:

  • To clarify the relationship between myocardial damage and platelet-neutrophil aggregation in patients with AMI.
  • To determine if neutrophil density in thrombus predicts clinical outcomes in ST-segment elevation AMI.

Main Methods:

  • Studied 107 patients with ST-segment elevation AMI undergoing percutaneous coronary intervention.
  • Categorized patients into low (L) and high (H) neutrophil density groups based on aspirated thrombus analysis.
  • Assessed myocardial blush grade (MBG), ST-segment resolution (STR), peak creatine kinase, and left ventricular ejection fraction (LVEF).

Main Results:

  • Group H (high neutrophil density) showed significantly more frequent poor MBG (
  • Peak creatine kinase levels tended to be higher, and LVEF at 6 months was lower in group H.
  • Multivariate analysis identified high neutrophil density as an independent predictor of adverse outcomes (MBG

Conclusions:

  • Platelet-neutrophil aggregates in thrombi may impair coronary microcirculation, leading to myocardial necrosis and dysfunction.
  • The interaction between thrombosis and inflammation is clinically significant in AMI pathogenesis.
  • Neutrophil density in thrombus is a potential prognostic marker for AMI patients.
Abstract

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