Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoimmune pancreatitis as a risk factor of pancreatic cancer.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2025
Same author

Perioperative systemic therapy as a part of comprehensive multimodal treatment in esophageal and gastric cancer - new treatment guidelines.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2024
Same author

Abdominal emergencies in surgical oncology.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2023
Same author

IgG4 Sclerosing Cholangitis - an Inflammation Imitating Tumour of the Pancreas and Biliary Tract.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2019
Same author

The timing of ERCP in acute biliary pancreatitis.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2019
Same author

Gastrointestinal tract and Russell bodies - a case report of Russell body carditis and review of the literature.

Acta gastro-enterologica Belgica·2018
Same journal

Hepatic steatosis integrated approach: nutritional guidelines and joined nutraceutical administration.

Minerva gastroenterologica e dietologica·2021
Same journal

Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review.

Minerva gastroenterologica e dietologica·2020
Same journal

Helicobacter pylori and non-alcoholic fatty liver disease.

Minerva gastroenterologica e dietologica·2020
Same journal

Hypertriglyceridemic pancreatitis.

Minerva gastroenterologica e dietologica·2020
Same journal

Effectiveness of percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis.

Minerva gastroenterologica e dietologica·2020
Same journal

Noninvasive diagnosis of fibrosis in non-alcoholic fatty liver disease: diagnostic accuracy of different scores.

Minerva gastroenterologica e dietologica·2020
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Autoimunne pancreatitis.

P Dite1, J Trna, I Novotny

  • 1Department of Hepatogastroenterology, University Hospital of Brno, Brno, Czech Republic. pdite@med.muni.cz

Minerva Gastroenterologica E Dietologica
|December 3, 2008
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis (AIP) is a chronic fibroinflammatory condition affecting the pancreas, often involving other organs. High serum IgG4 levels and steroid therapy are key characteristics of this atypical pancreatitis.

More Related Videos

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Autoimmune mechanisms have been implicated in pancreatitis since 1961.
  • Autoimmune pancreatitis (AIP) is increasingly recognized as a distinct entity.
  • Autoimmunity is a recognized risk factor in chronic pancreatitis classification (TIGARO, 2001).

Purpose of the Study:

  • To describe the characteristics of autoimmune pancreatitis (AIP).
  • To highlight the extrapancreatic manifestations of AIP.
  • To discuss the diagnostic and therapeutic aspects of AIP.

Main Methods:

  • Review of clinical, biochemical, and imaging findings in AIP.
  • Histopathologic examination of pancreatic and extrapancreatic lesions.
  • Analysis of serum IgG4 concentrations.

Main Results:

  • AIP presents as chronic fibroinflammatory pancreatitis with characteristic imaging findings.
  • Elevated serum IgG4 concentrations are a hallmark of AIP.
  • Extrapancreatic involvement, including sclerosing cholangitis and retroperitoneal fibrosis, is common, showing similar histopathology.

Conclusions:

  • AIP is a systemic fibroinflammatory disorder with potential digestive system involvement.
  • Diagnosis relies on characteristic clinical, biochemical, and imaging features.
  • Steroids represent a primary treatment modality for AIP.