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Inhibitors of Viral Protein Synthesis

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

Inhibitors Of Virion Release

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Antiviral Nucleoside Inhibitors

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Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Antimicrobial Proteins

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Related Experiment Video

Updated: Jun 27, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Interferons and their use in persistent viral infections.

Stéphane Chevaliez¹, Jean-Michel Pawlotsky

¹French National Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.

Handbook of Experimental Pharmacology

|December 3, 2008

Summary

Interferon (IFN) therapy, particularly recombinant IFN-alpha, is a key treatment for chronic hepatitis C and B virus infections. This review explores IFN

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Rescue of Recombinant Newcastle Disease Virus from cDNA

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Last Updated: Jun 27, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

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Published on: March 24, 2015

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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Published on: June 14, 2018

Rescue of Recombinant Newcastle Disease Virus from cDNA

Rescue of Recombinant Newcastle Disease Virus from cDNA

Published on: October 11, 2013

Area of Science:

Immunology
Virology
Biochemistry

Background:

Interferon (IFN) discovery celebrated its 50th anniversary in 2007.
The IFN-alpha gene was cloned, sequenced, and produced recombinantly.
Recombinant IFN-alpha is a cornerstone therapy for chronic hepatitis C and certain chronic hepatitis B infections.

Purpose of the Study:

To review the antiviral mechanisms of interferons.
To assess the utility of interferons in treating persistent viral infections.

Main Methods:

Literature review of interferon research and clinical applications.
Analysis of scientific data on interferon's role in viral infections.

Main Results:

Recombinant IFN-alpha is effective for chronic hepatitis C and B.
IFNs have shown variable success in other viral infections.

Conclusions:

Interferons possess significant antiviral properties.
IFN-alpha is a valuable therapeutic agent for specific persistent viral infections.