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Updated: Jun 27, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Restless legs syndrome in pediatric patients with chronic kidney disease
Garrick A Applebee1, Ann P Guillot, Catherine C Schuman
1University of Vermont College of Medicine, Burlington, VT 05401, USA. garrick.applebee@vtmednet.org
Insights
Restless Legs Syndrome (RLS) affects 35% of children with chronic kidney disease (CKD). Early screening for RLS in pediatric CKD patients is recommended, as it is more common than in the general population.
Area of Science:
- Pediatric Nephrology
- Sleep Medicine
- Clinical Research
Background:
- Sleep disorders are common in children with chronic kidney disease (CKD).
- Restless Legs Syndrome (RLS) prevalence and impact in pediatric CKD are not well-understood.
- Previous research indicates a higher incidence of sleep disturbances in CKD patients.
Purpose of the Study:
- To determine the prevalence of Restless Legs Syndrome (RLS) in children across various stages of chronic kidney disease (CKD).
- To evaluate the impact of RLS on sleep patterns and daytime functioning in pediatric CKD patients.
- To compare RLS prevalence in pediatric CKD to the general population.
Main Methods:
- A survey was conducted with 26 pediatric patients with varying stages of CKD.
- Data collected included RLS assessment, sleep schedules, and daytime sleepiness.
- Clinic-based and telephone survey methods were utilized.
Main Results:
- 35% of children with CKD met the criteria for Restless Legs Syndrome (RLS).
- The majority of children with RLS were in CKD stages 1-4.
- No significant differences in sleep schedule or daytime sleepiness were observed between children with and without RLS.
Conclusions:
- There is an increased prevalence of Restless Legs Syndrome (RLS) in children with chronic kidney disease (CKD) compared to the general population.
- Routine screening for RLS symptoms is advisable for all children diagnosed with any stage of CKD.
- Further research may explore the specific mechanisms linking CKD and RLS in children.
Abstract:
Sleep disorders have been shown to be more prevalent in adults and children with chronic kidney disease (CKD) and on dialysis. To date, the prevalence and impact of restless legs syndrome (RLS) in various stages of CKD has not been evaluated. The object of this study was to determine the prevalence of RLS in children with CKD in different stages, and to evaluate its impact on sleep and daytime functioning. We conducted a clinic-based or telephone survey of 26 patients in varying stages of CKD to assess for RLS, sleep schedule, and daytime sleepiness. Thirty-five percent of children met criteria for RLS, the majority being in CKD stages 1-4. There were no significant differences seen in sleep schedule and daytime sleepiness between those children with or without RLS. We found that there is an increased prevalence of RLS in children with CKD compared to the general population. This suggests that children with all stages of CKD should be routinely screened for RLS symptoms.
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