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An analysis of positive inotropic effects of nitroglycerin in the canine hearts
1Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
General Pharmacology
|January 1, 1991
Abstract:
1. Nitroglycerin caused dose-dependent increases in regional myocardial contractile force (MCF) in open-chest dogs, along with dose-dependent decreases in left ventricular end-diastolic (LVEDP) and arterial pressures and an increase in plasma catecholamines level. 2. The increase in MCF could not be completely prevented by propranolol along with a slight decrease in LVEDP and no increase in heart rate, although a nifedipine-produced increase in MCF without a significant decrease in LVEDP disappeared with propranolol despite the same decrease in arterial pressure.