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Updated: Jun 27, 2026

Multimodality Diagnosis of Mesenteric Ischemia

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Published on: July 21, 2023

Biomarkers in abdominal imaging.

Bernard E Van Beers¹, Valérie Vilgrain

¹Department of Radiology, Beaujon Hospital, Université Paris Diderot and INSERM U 773, 100 Boulevard du Général Leclerc, 92110 Clichy, France. bernard.van-beers@bjn.aphp.fr

Abdominal Imaging

|December 3, 2008

Summary

This summary is machine-generated.

Imaging biomarkers offer non-invasive assessment for abdominal diseases and cancer, aiding treatment response evaluation. Further validation is needed for widespread clinical adoption of these advanced imaging tools.

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Area of Science:

Radiology and Medical Imaging
Oncology
Gastroenterology

Background:

Imaging biomarkers provide non-invasive, spatially and temporally resolved measurements for disease detection, staging, grading, and treatment response assessment.
Traditional anatomical imaging biomarkers (e.g., RECIST criteria) often lack sensitivity for early treatment response evaluation in abdominal diseases, including cancer.
Molecular and functional imaging biomarkers show promise but require further development and validation.

Purpose of the Study:

To review the role and potential of various imaging biomarkers in managing abdominal diseases.
To highlight the advantages of imaging biomarkers over conventional markers.
To discuss the limitations and future directions for imaging biomarker implementation.

Main Methods:

Review of anatomical, molecular, and functional imaging biomarkers.
Discussion of imaging techniques including positron-emission tomography (PET), perfusion MRI, diffusion-weighted MRI, and MR spectroscopy.
Analysis of current applications and limitations in abdominal diseases and cancer.

Main Results:

Imaging biomarkers offer significant advantages in non-invasiveness and detailed resolution compared to biochemical or histological markers.
Functional imaging biomarkers demonstrate potential in patient selection and treatment response assessment for new therapies.
Current limitations include narrow target specificity for molecular biomarkers and the need for standardization and validation for functional biomarkers.

Conclusions:

Imaging biomarkers are valuable tools for abdominal diseases, with functional biomarkers showing particular promise for personalized medicine.
Significant efforts in validation and standardization are crucial for the widespread clinical adoption of imaging biomarkers.
Continued research is essential to fully realize the potential of imaging biomarkers in improving patient outcomes.