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High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC

Published on: February 2, 2024

Three new xanthones from Garcinia xanthochymus.

Fang-fang Zhong¹, Yu Chen, Fa-jun Song

¹Laboratory for Natural Product Chemistry, College of Life Sciences, South Central University for Nationalities, Wuhan 430074, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica

|December 4, 2008

Summary

Researchers isolated and identified three new xanthones from Garcinia xanthochymus bark. These compounds, including novel trihydroxy methoxyxanthones, were purified using advanced chromatography techniques.

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Area of Science:

Natural Product Chemistry
Phytochemistry
Organic Chemistry

Background:

Garcinia species are known sources of bioactive secondary metabolites.
Xanthones are a significant class of compounds found in Garcinia, exhibiting diverse biological activities.
Garcinia xanthochymus bark is a potential source for novel xanthone discovery.

Purpose of the Study:

To isolate and characterize xanthone constituents from the bark of Garcinia xanthochymus.
To identify novel xanthone structures using spectroscopic methods.
To contribute to the understanding of the phytochemical diversity within the Garcinia genus.

Main Methods:

Extraction of secondary metabolites from Garcinia xanthochymus bark using ethyl acetate (EtOAc).
Isolation of compounds via normal-phase and reverse-phase silica gel column chromatography.

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Last Updated: Jun 27, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC

Published on: February 2, 2024

Structure elucidation of purified compounds using comprehensive spectral analysis (e.g., NMR, MS).

Main Results:

Three new xanthone derivatives were successfully isolated and purified.
The identified compounds are 1,2,5-trihydroxy-6-methoxyxanthone (1), 1,4,6-trihydroxy-5-methoxyxanthone (2), and 1,2,7-trihydroxy-4-(1,1-dimethylallyl) xanthone (3).
The structures were confirmed through detailed analysis of their spectral data.

Conclusions:

The study successfully identified three previously unknown xanthone compounds from Garcinia xanthochymus.
These findings expand the known chemical diversity of xanthones from this plant species.
The isolated xanthones represent potential leads for further pharmacological investigations.