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Published on: April 9, 2014
[Comparative efficiency and side effects of combined antiviral therapy of chronic hepatitis C]
Abstract:
The study included 100 patients with chronic hepatitis C previously untreated by interferon preparations. Patients of group I (n=53) were given pegylated interferon alpha-2b (PEG IFN) and rebetol, patients of group 2 (n=47) PEG IFN and copegus. The overall efficiency of therapy regardless of hepatitis C virus genotype in the two groups was estimated at 83 and 79% respectively. It was 65% in patients with virus genotype 1b in group 1 and 69% in group 2 In patients with virus genotypes 2 and 3, the efficiency was estimated at 100 and 91% in groups 1 and 2 respectively. The efficiency of therapy depended on the duration of the period during which the virological response was obtained. Side effects in the form of disturbed sleep, musculo-articular pain, and anorexia occurred in group 1 more frequently than in group 2 The reverse was true of scalp reactions and psycho-emotional distress.
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