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Related Experiment Video

Updated: Jun 27, 2026

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Sensor array made with nanostructured films to detect a phenothiazine compound.

P H B Aoki1, W Caetano, D Volpati

  • 1DFQB, Faculdade de Ciências e Tecnologia, UNESP, Presidente Prudente/SP, 19060-900, Brazil.

Journal of Nanoscience and Nanotechnology
|December 4, 2008
PubMed
Summary

An electronic tongue with six sensors detected trace amounts of methylene blue (MB) down to 1 nM. This sensor array shows high sensitivity for medical and pharmaceutical applications.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biosensors

Background:

  • Accurate detection of phenothiazines is crucial for medical and pharmaceutical industries.
  • Developing fast, direct detection methods is an ongoing challenge.

Purpose of the Study:

  • To explore the use of an electronic tongue for detecting trace amounts of methylene blue (MB).
  • To evaluate the sensitivity and cross-sensitivity of a sensor array for MB detection.

Main Methods:

  • A sensor array comprising six units was fabricated using various electrode coatings, including Langmuir-Blodgett (LB) films and physical vapor deposition (PVD) films.
  • Impedance spectroscopy was used to measure the electrical response of the sensor array.
  • Principal Component Analysis (PCA) was applied to capacitance data at 1 kHz for data analysis.

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Last Updated: Jun 27, 2026

A Polyaniline-based Sensor of Nucleic Acids
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Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
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Main Results:

  • The sensor array exhibited varied electrical responses across different sensing units, indicating good cross-sensitivity.
  • The electronic tongue successfully distinguished MB solutions from ultrapure water down to 1 nM concentration.
  • Phospholipid-based sensing units (DPPC and DPPG) showed the most significant contribution to MB detection, suggesting strong interactions.

Conclusions:

  • The developed electronic tongue demonstrates unprecedented sensitivity for MB detection.
  • Electrical measurements in ultrathin films are highly sensitive, even when bulk interactions are not evident.
  • This technology holds promise for sensitive and direct detection in medical and pharmaceutical analysis.