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Severe optic neuropathy caused by dichloromethane inhalation
Atsushi Kobayashi1, Akira Ando, Nobuko Tagami
1Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
Summary
Severe optic neuropathy resulted from dichloromethane inhalation. This case highlights the central nervous system toxicity of organic solvents, leading to poor visual outcomes.
Area of Science:
- Neuroscience
- Toxicology
- Ophthalmology
Background:
- Dichloromethane (DCM) is a common industrial solvent.
- Inhalation of volatile organic compounds can lead to severe health consequences.
- Optic neuropathy is a serious condition affecting vision.
Observation:
- A 65-year-old man experienced unconsciousness after cleaning a DCM tank.
- He developed progressive visual field narrowing and decreased visual acuity.
- Ophthalmic examinations revealed optic nerve damage despite normal retinal findings.
Findings:
- The patient was diagnosed with optic neuropathy due to organic solvent poisoning.
- Carbon monoxide toxicity from DCM metabolism and direct DCM effects were implicated.
- Despite treatment, optic nerve atrophy and visual evoked cortical potential abnormalities worsened.
Implications:
- This case underscores the potential for severe central nervous system and optic nerve damage from DCM exposure.
- Early recognition and management of solvent-induced optic neuropathy are crucial.
- Further research into the neurotoxic mechanisms of DCM is warranted.
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