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A structural resolution cryo-TEM study of the early stages of MFI growth

Sandeep Kumar1, Zhuopeng Wang, R Lee Penn

  • 1University of Minnesota, Department of Chemical Engineering and Materials Science, 151 Amundson Hall, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA.

Journal of the American Chemical Society
|December 4, 2008
PubMed

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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...