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Gender disparity in a large nonreferral-based cohort of hypertrophic cardiomyopathy patients

M Brimacombe1, D Walter, L Salberg

  • 1Department of Preventive Medicine, NJMS-UMDNJ, Newark, New Jersey 07101-1709, USA. brimacmbe@umdnj.edu

Journal of Women'S Health (2002)
|December 4, 2008
PubMed

Insights

Women with hypertrophic cardiomyopathy (HCM) report more symptoms and take more non-HCM medications than men. This patient database offers insights into diverse HCM experiences.

Area of Science:

  • Cardiology
  • Genetics
  • Patient Advocacy

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease affecting 1 in 500 individuals.
  • HCM presents with high variability in clinical symptoms and severity.
  • Existing research often relies on hospital-based or referral populations.

Purpose of the Study:

  • To investigate gender-based differences in self-reported symptoms and medication use among HCM patients.
  • To leverage the Hypertrophic Cardiomyopathy Association (HCMA) database for insights into a diverse, non-referral patient population.

Main Methods:

  • Utilized data from 1228 HCM patients within the HCMA database.
  • Employed phone interviews and mailed surveys for data collection from consenting patients.
  • Analyzed self-reported symptom and medication patterns, comparing male and female participants.

Main Results:

  • Females were more likely than males to report a family history of HCM, chest pain, fatigue, lightheadedness, and palpitations.
  • A higher percentage of females (44.9%) reported four or five symptoms compared to males (31.4%).
  • Females were also more likely to be taking non-HCM-related medications.

Conclusions:

  • The HCMA database provides a valuable resource for studying non-hospital-based HCM patient cohorts.
  • Significant gender-related disparities exist in HCM symptom profiles and medication use.
  • Findings are subject to the limitations inherent in self-reported data and the study's design.
Abstract

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