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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Thrombolysis in recurrent lacunar stroke: a case example.

T H Nguyen1, D Vo, M B Ngo

  • 1Department of Neurology, People Hospital, Vietnam. dr_nguyenhuythang@yahoo.com

European Journal of Neurology
|December 4, 2008
PubMed
Summary
This summary is machine-generated.

Intravenous thrombolysis may be safe for early recurrent lacunar stroke. This treatment led to significant improvement in a patient who experienced a second stroke within a week of the first.

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Emergency Medicine

Background:

  • Early recurrent stroke presents a significant clinical challenge.
  • Lacunar infarcts, though often small, can lead to severe disability.
  • Timely intervention is crucial for improving outcomes in recurrent stroke.

Observation:

  • A 62-year-old male experienced a lacunar infarct in the left putamen with near-complete recovery.
  • Seven days post-initial stroke, the patient suffered a recurrent ischemic event (left internal capsule infarct).
  • Symptoms of recurrent stroke appeared rapidly, necessitating urgent treatment.

Findings:

  • Intravenous thrombolysis with alteplase (0.9 mg/kg) was administered 40 minutes after symptom onset of the recurrent stroke.
  • The patient demonstrated significant neurological improvement following thrombolytic therapy.
  • This case suggests a potential benefit of thrombolysis in specific recurrent stroke scenarios.

Implications:

  • Intravenous thrombolysis could be a viable option for early recurrent lacunar stroke.
  • Patient selection, considering hemorrhage risk, is critical for safe thrombolysis in recurrent stroke.
  • Further research is warranted to establish the safety and efficacy of thrombolysis for early recurrent ischemic events.