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Human bocavirus infection in children with acute gastroenteritis and healthy controls

Thaweesak Chieochansin1, Chitima Thongmee, Linda Vimolket

  • 1Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Japanese Journal of Infectious Diseases
|December 4, 2008
PubMed

Insights

Human bocavirus (HBoV) causes respiratory illness in children. This study found HBoV in 0.9% of children with gastroenteritis but not in healthy controls, indicating a potential role in gut infections.

Area of Science:

  • Virology
  • Pediatrics
  • Gastroenterology

Background:

  • Human bocavirus (HBoV) is a recently identified virus.
  • HBoV is known to cause respiratory tract disease in infants and children.
  • Previous research has focused on HBoV in the respiratory tract.

Purpose of the Study:

  • To investigate the prevalence of HBoV in the gastrointestinal tract.
  • To determine if HBoV is associated with acute gastroenteritis in children.
  • To analyze the genetic sequences of detected HBoV strains.

Main Methods:

  • Stool samples were collected from children with acute gastroenteritis and healthy controls.
  • HBoV detection was performed using molecular methods.
  • Complete coding sequences of detected HBoV were analyzed for conservation.

Main Results:

  • HBoV was detected in 0.9% of stool samples from children with acute gastroenteritis.
  • No HBoV was detected in stool samples from healthy control children.
  • The complete coding sequences of the detected HBoV strains exhibited highly conserved sequences.

Conclusions:

  • HBoV may play a role in acute gastroenteritis in children.
  • The findings suggest HBoV can infect the gastrointestinal tract.
  • Sequence conservation implies limited viral evolution in the studied strains.

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