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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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[Can systemic treatment for lymph node metastases be given with curative intent?].

T Gauler1, M Schuler

  • 1Innere Klinik (Tumorforschung), Universitätsklinikum , Hufelandstrasse 55, 45122 Essen. thomas.gauler@uk-essen.de

Der Urologe. Ausg. A
|December 4, 2008
PubMed
Summary

Systemic therapy offers curative potential for advanced germ cell tumors with chemotherapy. For other urological cancers, its role is primarily palliative or investigational in the adjuvant setting.

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Area of Science:

  • Uro-oncology
  • Medical oncology
  • Clinical research

Context:

  • Locally advanced urological cancers present complex treatment challenges.
  • Lymph node metastasis requires effective systemic treatment strategies.
  • The curative potential of systemic therapy varies significantly by urological tumor type.

Purpose:

  • To review the role of systemic therapy in the curative treatment of advanced urological cancers.
  • To delineate specific indications for systemic treatment in germ cell, urothelial, renal cell, and prostate cancers.
  • To highlight current research directions for systemic therapies in urological oncology.

Summary:

  • Platinum-based polychemotherapy can achieve cures in advanced germ cell tumors, including high-risk cases.
  • For urothelial cancers, chemotherapy is mainly used in the neoadjuvant/adjuvant setting with surgery.
  • Renal cell cancer is curable by surgery; systemic therapies (cytokines, targeted agents) are options for advanced disease and are being investigated in the adjuvant setting.
  • Prostate cancer management for locally advanced disease involves hormone ablation therapy, with adjuvant roles under investigation.

Impact:

  • Establishes germ cell tumors as curable with systemic chemotherapy.
  • Defines the current limited role of systemic therapy in other advanced urological malignancies.
  • Identifies ongoing clinical trials exploring adjuvant systemic treatments for renal cell and prostate cancers.
  • Provides a concise overview for clinicians and researchers on systemic therapy in urological oncology.