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Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
Published on: September 11, 2020
A new twist on an old problem: a case of pediatric meningitis caused by multidrug-resistant Streptococcus pneumoniae
W Ciccotelli1, S Poutanen, S Morris
1Department of Infectious Diseases and Medical Microbiology, McMaster University, Hamilton, Ontario, Canada.
Abstract:
Recent studies show that multidrug-resistant Streptococcus pneumoniae serotype 19A continues to emerge as a cause of invasive pneumococcal disease after the introduction of Prevnar. We report a case of multidrug-resistant S. pneumoniae serotype 19A meningitis successfully treated with vancomycin and levofloxacin. This case reinforces the need for the empiric use of vancomycin in meningitis and the need for alternative treatments.
Insights
Multidrug-resistant Streptococcus pneumoniae serotype 19A causes invasive pneumococcal disease. A case of 19A meningitis was successfully treated with vancomycin and levofloxacin, highlighting treatment needs.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Multidrug-resistant Streptococcus pneumoniae serotype 19A is an emerging pathogen causing invasive pneumococcal disease.
- The prevalence of serotype 19A has increased following the introduction of pneumococcal conjugate vaccines like Prevnar.
Observation:
- A case of meningitis caused by multidrug-resistant Streptococcus pneumoniae serotype 19A was reported.
- The patient presented with symptoms indicative of severe pneumococcal infection.
Findings:
- The meningitis case was successfully treated with a combination of vancomycin and levofloxacin.
- This treatment regimen proved effective against the multidrug-resistant strain.
Implications:
- The findings underscore the importance of empiric vancomycin use in suspected meningitis cases.
- Alternative treatment strategies are crucial for managing infections caused by resistant Streptococcus pneumoniae strains.
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