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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Updated: Jun 27, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Radiation-induced sarcoma: analysis of 46 cases.

S De Smet¹, L Vandermeeren, M-R Christiaens

¹Department of Surgical Oncology, Leuven University Hospital, Leuven, Belgium.

Acta Chirurgica Belgica

|December 5, 2008

Summary

Radiation-induced sarcomas are rare but aggressive. Radical surgical resection offers the best chance for survival in patients who develop sarcoma after radiotherapy.

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Area of Science:

Oncology
Radiation Oncology
Surgical Oncology

Background:

Sarcomas can develop in previously irradiated tissues.
These secondary sarcomas are often aggressive and challenging to treat.

Purpose of the Study:

To analyze the clinical characteristics, treatment, and outcomes of sarcomas arising in previously irradiated areas.
To identify prognostic factors for radiation-induced sarcomas.

Main Methods:

Retrospective analysis of 46 sarcoma cases treated between 1989 and 2007.
Review of patient demographics, treatment history (radiotherapy details), sarcoma type, clinical presentation, surgical intervention, and survival data.

Main Results:

Median interval from radiotherapy to sarcoma diagnosis was 15 years.
Common presentations included mass, pain, and skin changes.
Angiosarcoma and sarcoma not otherwise specified were most frequent.
5-year survival was 45% with radical resection, but 0% with non-radical resection or no surgery.
Stage and location significantly impacted prognosis.

Conclusions:

Radiation-induced sarcomas require careful consideration due to their aggressive nature.
Radical surgical resection is crucial for improving survival outcomes.
Timely diagnosis and appropriate management are essential for patients with secondary sarcomas.