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[Participation of 5-HT 1A receptors in the decrease by serotonin of activation of locus coeruleus neurons by
P J Charlety1, G Aston-Jones, H Akaoka
1I.N.S.E.R.M., U 171 et C.N.R.S., U.A. 1195, Centre hospitalier Lyon-Sud, Pierre-Bénite.
Abstract:
The serotonin-induced decrease of glutamate-evoked activation of noradrenergic locus coeruleus neurons is mimicked by agonists of 5-HT 1 and 1A but not by 5-HT 1B or by 5-HT 2 agonists. Moreover, this effect is reversed by a broad-spectrum 5-HT antagonist but not by a 5-HT 2 antagonist, indicating that this effect is mediated primarily through 5-HT 1A receptors.