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Role of astrovirus in intussusception in Nigerian infants

M Aminu1, E A Ameh, A Geyer

  • 1Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria. maryamaminu@yahoo.com

Journal of Tropical Pediatrics
|December 5, 2008
PubMed

Insights

Astrovirus was detected in infant intussusception (IS) cases. Further research is needed to understand astrovirus

Area of Science:

  • Pediatrics
  • Virology
  • Gastroenterology

Background:

  • Intussusception (IS) is a critical intestinal obstruction.
  • Viral infections are implicated in 20-50% of childhood IS cases.
  • Commonly implicated viruses include adenovirus and enterovirus.

Purpose of the Study:

  • To investigate the presence of rotavirus, astrovirus, and adenovirus in infants with IS.
  • To determine the role of astrovirus in infant intussusception.

Main Methods:

  • Enzyme immune assay (EIA) for antigen detection.
  • Reverse transcription-polymerase chain reaction (RT-PCR) for confirmation.
  • Analysis of six infant stool specimens (0-8 months old).

Main Results:

  • Astrovirus antigen detected in 3 of 6 specimens via EIA.
  • Astrovirus confirmed in 2 specimens via RT-PCR.
  • Mixed infections (rotavirus, adenovirus, astrovirus) identified in one specimen.

Conclusions:

  • Astrovirus is detected in infant intussusception cases.
  • Further studies are required to establish astrovirus' role in IS etiology.
  • Astrovirus should be considered in future IS etiological investigations.

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