Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retiform Purpura Due to Microvascular Occlusion: An Archetypical Manifestation of Lucio Phenomenon in Lepromatous Leprosy.

The American journal of tropical medicine and hygiene·2026
Same author

Serum Neurofilament Light Chain Levels in Leprosy Patients: A Cross-Sectional Study.

Tropical medicine & international health : TM & IH·2026
Same author

Evidence of Increased 3-Alpha-Androstanediol Glucuronide in Female Pattern Alopecia: A Cross-Sectional Observational Study Evaluating Ovarian, Adrenal, and Peripheral Androgens.

International journal of dermatology·2026
Same author

What Are the Histological Changes Corresponding to Clinical Effacement of Atrophic Acne Scars After Fractional Carbon Dioxide Laser Intervention-A Prospective Interventional Study in Skin of Color.

Photodermatology, photoimmunology & photomedicine·2026
Same author

Authors' Response to Comment on published article "A Real-World Study of Tofacitinib in Indian Patients with Refractory Moderate-to-Severe Atopic Dermatitis, its Economic Considerations and Immunological Rationale".

Indian dermatology online journal·2026
Same author

Oral Tofacitinib for Refractory Lichen Planus Pigmentosus Coexisting with Frontal Fibrosing Alopecia.

Indian dermatology online journal·2026

Related Experiment Video

Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Therapeutic trials for systemic sclerosis: an update.

Kabir Sardana1, V K Garg

  • 1Department of Dermatology, Maulana Azad Medical College and Lok Nayak Hospital, Delhi, India. kabirijdvl@gmail.com

Indian Journal of Dermatology, Venereology and Leprology
|December 5, 2008
PubMed
Summary

Systemic sclerosis (SSc) pathogenesis remains complex, complicating clinical trials. Early diagnosis and identifying patients for aggressive treatment are crucial for better outcomes in this autoimmune disease.

Related Experiment Videos

Last Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic sclerosis (SSc) exhibits complex pathogenesis, with ongoing research to fully elucidate its mechanisms.
  • The disease presents significant clinical heterogeneity, diverse autoimmune profiles, and a variable disease course, including spontaneous remission, posing challenges for therapeutic development.

Purpose of the Study:

  • To review data from recent clinical trials in systemic sclerosis.
  • To derive lessons from these trials to improve future research and patient management.

Main Methods:

  • Review of existing clinical trial data for systemic sclerosis.
  • Analysis of challenges and successes in SSc clinical trial design.

Main Results:

  • Clinical trial design in SSc is hindered by disease heterogeneity and unpredictable course.
  • Identifying patients who will benefit from early, aggressive treatment is a key unmet need.

Conclusions:

  • Early diagnosis and targeted treatment strategies are paramount for improving outcomes in systemic sclerosis.
  • Lessons learned from past clinical trials are essential for advancing SSc research and therapy.