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Allergic Reactions02:06

Allergic Reactions

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Related Experiment Video

Updated: Jun 27, 2026

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
06:31

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Published on: October 3, 2019

Atopic patch testing.

D S Krupa Shankar1, M Chakravarthi

  • 1Department of Dermatology, Manipal Hospital, Bangalore, India.

Indian Journal of Dermatology, Venereology and Leprology
|December 5, 2008
PubMed
Summary

The atopic patch test is effective in diagnosing allergen triggers for atopic dermatitis. Parthenium was identified as the most common allergen in Bangalore, aiding in patient management.

Area of Science:

  • Dermatology
  • Allergology
  • Clinical Immunology

Background:

  • Atopic dermatitis is a prevalent skin condition, particularly in urban areas.
  • Allergens frequently trigger or exacerbate atopic dermatitis symptoms.
  • The atopic patch test serves as a diagnostic method for identifying allergen triggers.

Purpose of the Study:

  • To evaluate the efficacy of the atopic patch test in reproducing eczematous reactions.
  • To identify specific allergens associated with atopic dermatitis.
  • To determine individual allergens that cause or worsen atopic dermatitis.

Main Methods:

  • Seventy-five patients diagnosed with atopic dermatitis participated in the study.
  • Prick test allergens were applied to intact skin on the back under occlusion.

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  • Reactions were assessed at 48 and 72 hours post-application.
  • Main Results:

    • Positive reactions to patch testing were observed in 47% of the subjects.
    • Parthenium was identified as the most frequent allergen, responsible for 42% of positive reactions.
    • The study highlights the prevalence of Parthenium allergy in the Bangalore population.

    Conclusions:

    • Epicutaneous application of allergens via patch testing can elicit reactions in susceptible individuals.
    • Parthenium is a significant allergen contributing to atopic dermatitis in Bangalore.
    • Patch test results can guide patient counseling, potentially improving quality of life and reducing disease severity.