Related Experiment Video
Updated: Jun 27, 2026
10:18
Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
Published on: July 7, 2023
Peptide-based vaccines for cancer: realizing their potential
Shreya Kanodia1, W Martin Kast
1Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, NRT 7517, University of Southern California, 1450 Biggy Street, Los Angeles, CA 90033, USA. skant@usc.edu
Expert Review of Vaccines
|December 5, 2008
Summary
Advances in peptide engineering, adjuvants, and delivery systems are driving new cancer vaccine trials. Overcoming common immunotherapy challenges is key to future success for peptide-based cancer vaccines.
Area of Science:
- Oncology
- Immunology
- Biotechnology
Background:
- Peptide-based vaccination is regaining interest for cancer immunotherapy.
- Numerous clinical trials are underway, driven by pharmaceutical companies.
Purpose of the Study:
- To review advancements in peptide identification, design, and delivery for cancer vaccines.
- To discuss challenges in cancer immunotherapy and future directions.
Main Methods:
- Literature review of peptide engineering, adjuvants, and delivery systems.
- Analysis of current challenges in cancer immunotherapy.
- Exploration of future strategies for peptide-based vaccines.
Main Results:
- Significant progress has been made in peptide, adjuvant, and delivery system engineering.
- Challenges in cancer immunotherapy are not unique to peptide vaccines and are shared across strategies.
Conclusions:
- Peptide-based cancer vaccines show promise, supported by technological advances.
- Addressing common immunotherapy hurdles is crucial for realizing the full potential of peptide vaccines.
More Related Videos
Related Concept Videos
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:21Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
01:51Vaccinations
Overview
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...