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Updated: Jun 27, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Parallel synthesis of trisubstituted formamidines: a facile and versatile procedure
Andrea Porcheddu1, Giampaolo Giacomelli, Ivana Piredda
1Dipartimento di Chimica, Università degli Studi di Sassari, Sassari, Italy. anpo@uniss.it
Abstract:
A focused library of formamidines having several diversity points has been prepared. The use of isocyanate resin as scavenger may offer several practical advantages over conventional procedures, such as the ease of workup and availability. The technique described herein was performed in a parallel synthesis format. The whole protocol has potential use in high throughput synthesis for the preparation and purification of libraries of unsymmetrical formamidines containing sets of different aliphatic substituents.
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