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Published on: April 18, 2019
Citreamicins with potent gram-positive activity
D Craig Hopp1, Dennis J Milanowski, Joshua Rhea
1AMRI, Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011, USA.
Abstract:
Two new xanthone antibiotics, citreamicin delta (1) and epsilon (2), with potent activity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus (MDRSA) were discovered. Compounds 1 and 2 exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from EtOAc extracts of Streptomyces vinaceus and were purified by countercurrent chromatography and reversed-phase HPLC. Their structures were elucidated using primarily NMR and mass spectroscopy.
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