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Antiplasmodial alkaloids from Desmos rostrata
Ngoc Tuan Nguyen1, Van Cuong Pham, Marc Litaudon
1Institute of Chemistry, VAST, 18 Hoang Quoc Viet Road, Caugiay, Hanoi.
Abstract:
Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).
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