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Published on: February 4, 2022
A cell wall-active lipopeptide from the fungus Pochonia bulbillosa
Frank E Koehn1, Donald R Kirsch, Xidong Feng
1Natural Products Discovery and Discovery Analytical Chemistry, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA. koehnf@wyeth.com
Abstract:
Bioassay-directed fractionation of a fermentation of Pochonia bulbinosa, culture 38G272, led to the isolation of a series of structurally novel, prospective cell wall-active lipopeptides. The main component of this suite is 1, a linear hexapeptide with a delta-hydroxymyristic acid amide substituted N-terminus. The structure was deduced using high-field microsample NMR, Fourier transform mass spectrometry, and microscale chemical degradation. The potent cell wall activity and synthetically accessible structure of 1 make it a potential lead for further investigation.
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