Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Computational prediction of C-H hydricities and their use in predicting the regioselectivity of electron-rich C-H functionalisation reactions.

Beilstein journal of organic chemistry·2026

Same author

Enhancing chemical synthesis planning: automated quantum mechanics-based regioselectivity prediction for C-H activation with directing groups.

Beilstein journal of organic chemistry·2025

Same author

SMILES all around: structure to SMILES conversion for transition metal complexes.

Journal of cheminformatics·2025

Same author

The need to implement FAIR principles in biomolecular simulations.

Nature methods·2025

Same author

Atom-based machine learning for estimating nucleophilicity and electrophilicity with applications to retrosynthesis and chemical stability.

Chemical science·2025

Same author

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.

Journal of chemical information and modeling·2024

Search research articles

Related Experiment Video

Updated: May 8, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Building a BioChemformatics database.

Jan H Jensen¹, Thomas Hoeg-Jensen, Søren B Padkjaer

¹Scientific Computing, Novo Nordisk Park A2P, Novo Nordisk A/S, DK-2760 Maaloev, Denmark. jan@jan-holst.dk

Journal of Chemical Information and Modeling

|December 5, 2008

Summary

This study introduces a novel BioChemInformatics database for efficient registration and retrieval of chemically modified macromolecules. This approach overcomes limitations of traditional databases, enabling better biopharmaceutical development.

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 8, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Area of Science:

Biochemistry
Bioinformatics
Drug Discovery

Background:

Chemically modified macromolecules are crucial for biopharmaceutical development.
Current databases struggle with performance for large, complex molecules, leading to loss of chemical detail.

Purpose of the Study:

To develop a high-performance system for registration and retrieval of chemically modified macromolecules.
To enable seamless integration of chemical and sequence information for biopharmaceutical research.

Main Methods:

Extension of protein formats using pseudoatoms to represent amino acids in chemical structures.
Parallel registration and retrieval in both sequence and chemistry formats.
Lossless conversion between chemical and sequence representations.

Main Results:

Development of a BioChemInformatics database enabling efficient data management.
Facilitation of combined sequence and chemistry searches.
Enabling construction of mixed sequence-chemistry protein SAR tables.

Conclusions:

The proposed method significantly improves the handling of complex macromolecules in databases.
This facilitates advanced biopharmaceutical research by integrating chemical and sequence data.
Enables versatile searching and data analysis for drug discovery and development.