Related Experiment Videos
[Candida parapsilosis infection as a complication of long-term parenteral nutrition]
S Buttenberg1, E L Grauel, R R Wauer
1Abteilung Neonatologie, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
Kinderarztliche Praxis
|January 1, 1991
Abstract:
In case of short bowel syndrome in infancy the total parenteral nutrition was complicated by catheter-associated Candida parapsilosis septicemia based on generalized enterococci infection. Specific problems in antifungal treatment are discussed.
Insights
Catheter-associated Candida parapsilosis septicemia complicated total parenteral nutrition in infants with short bowel syndrome. Antifungal treatment challenges for this serious infection were discussed.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Clinical Pharmacy
Background:
- Short bowel syndrome (SBS) in infancy often necessitates total parenteral nutrition (TPN).
- TPN support, while life-saving, carries risks including catheter-related bloodstream infections.
- Catheter-associated bloodstream infections (CABSI) are a significant concern in neonates receiving TPN.
Observation:
- A case of SBS in an infant on TPN presented with complicated septicemia.
- The infection was identified as Candida parapsilosis septicemia.
- The septicemia was superimposed on a generalized enterococci infection.
Findings:
- The study highlights the complexity of managing invasive fungal infections in neonates with SBS.
- Candida parapsilosis was the causative agent of septicemia in this TPN-dependent infant.
- Co-existing enterococcal infection presented a diagnostic and therapeutic challenge.
Implications:
- Effective antifungal strategies are crucial for improving outcomes in TPN-dependent infants with SBS.
- Understanding the interplay between bacterial and fungal pathogens is vital for appropriate treatment.
- This case underscores the need for vigilant monitoring and prompt management of infections in vulnerable neonatal populations.