In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups
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Updated: Jun 27, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
Mingyu Hu1, Junqi Li, Shao Q Yao
1Department of Chemistry, NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore 117543.
Abstract:
A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.
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