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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae)
Guillaume Marti1, Véronique Eparvier, Christian Moretti
1Institut de Chimie des Substances Naturelles, 1, avenue de la Terrasse, CNRS, 91198 Gif-sur-Yvette, France.
Abstract:
In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.
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