Related Experiment Video
Updated: Jun 27, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Ghrelin expression in normal kidney tissue and renal carcinomas
Adile F Dagli1, Suleyman Aydin, Aziz Karaoglu
1Department of Pathology, Firat University, Medical School, 23119 Elazig, Turkey.
Pathology, Research and Practice
|December 5, 2008
Summary
Ghrelin peptide expression is significantly reduced or absent in renal cell carcinoma and oncocytoma kidney tissues compared to normal kidney tissue. This diminished ghrelin may contribute to kidney cancer development and progression.
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- Ghrelin, a peptide hormone, exhibits variable expression patterns in different cancers.
- Understanding ghrelin's role in kidney cancer is crucial for potential therapeutic strategies.
Purpose of the Study:
- To compare ghrelin peptide expression in renal cell carcinoma, oncocytoma, and normal kidney tissues.
- To investigate correlations between tissue ghrelin levels and renal carcinoma.
- To establish normal kidney ghrelin expression levels relative to stomach tissue.
Main Methods:
- Radioimmunoassay (RIA) and immunohistochemistry were used to quantify ghrelin expression.
- Analysis included normal stomach and kidney samples, clear cell renal carcinomas, chromophobe RCC, papillary RCC, and oncocytomas.
Main Results:
- Renal cell carcinoma subtypes (clear cell, chromophobe, papillary) and oncocytomas showed significantly lower ghrelin expression than normal kidney tissue (ranging from 48% to 95% reduction).
- Ghrelin was often absent in renal cell carcinoma tissues.
- Normal kidney ghrelin levels were assessed in comparison to normal stomach tissue.
Conclusions:
- Ghrelin expression is consistently low or absent in renal cell carcinoma and oncocytoma tissues.
- Reduced ghrelin levels in kidney tumors may be implicated in the etiopathogenesis and progression of renal cancers.
Related Concept Videos
01:24Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
01:20Renal Corpuscle
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...