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A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
Andrea Ciammaruconi1, Stefania Gorini, Paola Londei
1Dpt. Biotecnologie Cellulari ed Ematologia, Università di Roma La Sapienza (Policlinico) Viale Regina Elena 324, 00161 Rome, Italy.
Abstract:
We have identified a novel archaeal protein that apparently plays two distinct roles in ribosome metabolism. It is a polypeptide of about 18 kDa (termed Rbp18) that binds free cytosolic C/D box sRNAs in vivo and in vitro and behaves as a structural ribosomal protein, specifically a component of the 30S ribosomal subunit. As Rbp18 is selectively present in Crenarcheota and highly thermophilic Euryarchaeota, we propose that it serves to protect C/D box sRNAs from degradation and perhaps to stabilize thermophilic 30S subunits.
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