Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlation between hypothalamic catecholamine synthesis and ether stress-induced ACTH secretion.

G A Hedge, J M van Ree, D H Versteeg

    Neuroendocrinology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Expression of preproNPY and precursor VIP mRNAs in rats under hypo- or hyperthyroid conditions.

    Molecular and cellular neurosciences·2009
    Same author

    Differential effects of neonatal 6-hydroxydopamine treatment on the catecholamine content of hypothalamic nuclei and brain stem regions.

    Neuroscience letters·2009
    Same author

    Regional effects of vasopressin on rat brain catecholamine metabolism.

    Neuroscience letters·2009
    Same author

    ECNP consensus meeting March 2003 guidelines for the investigation of efficacy in substance use disorders.

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2006
    Same author

    Contact allergy and respiratory/mucosal complaints from heroin (diacetylmorphine).

    Contact dermatitis·2006
    Same author

    Chronic cocaine injections attenuate behavioral response of kappa-opioid receptors to U-50,488H agonist.

    Bulletin of experimental biology and medicine·2005

    Stress increases the synthesis of norepinephrine and dopamine in the arcuate nucleus area (ANA) of the hypothalamus. These catecholamines in the ANA are involved in mediating ACTH secretion during ether stress.

    Area of Science:

    • Neuroendocrinology
    • Stress Physiology
    • Neurochemistry

    Background:

    • The hypothalamus plays a crucial role in regulating the stress response, including the secretion of adrenocorticotropic hormone (ACTH).
    • Catecholamines, such as norepinephrine (NE) and dopamine (DA), are neurotransmitters found in the hypothalamus that may influence hormonal responses to stress.

    Purpose of the Study:

    • To investigate the impact of different stressors on the synthesis rates of norepinephrine and dopamine in specific hypothalamic regions.
    • To determine if catecholamine synthesis in the hypothalamus is involved in the regulation of ACTH secretion during stress.

    Main Methods:

    • Rats were exposed to various stressors (ether vapor, cold, laparotomy) known to increase ACTH secretion.
    • Catecholamine synthesis rates were measured in vitro by assessing the accumulation of 3H-norepinephrine and 3H-dopamine from 3H-tyrosine in hypothalamic tissue.

    Related Experiment Videos

  • Plasma corticosterone levels were measured to confirm stress-induced ACTH secretion.
  • The effect of dexamethasone on stress-induced ACTH secretion and catecholamine synthesis was evaluated.

    • Main Results:

    • Ether stress, cold exposure, and laparotomy significantly increased plasma corticosterone levels, indicating elevated ACTH secretion.
    • Ether stress selectively increased the synthesis rates of both norepinephrine and dopamine in the arcuate nucleus area (ANA).
    • No significant changes in catecholamine synthesis rates were observed in the median eminence (ME) or residual hypothalamus (RH) under ether stress.
    • Dexamethasone administration blocked stress-induced ACTH secretion but did not alter basal or stress-induced catecholamine synthesis rates.

    Conclusions:

    • Catecholamines within the arcuate nucleus area (ANA) are implicated in mediating the ACTH secretory response to ether stress.
    • The synthesis of catecholamines in specific hypothalamic regions may be differentially regulated by stress.
    • These findings contribute to understanding the neurochemical mechanisms underlying the hypothalamic-pituitary-adrenal (HPA) axis regulation.