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Platelet function in clinically healthy cats and cats with hypertrophic cardiomyopathy: analysis using the Platelet
Karl E Jandrey1, Jeffrey W Norris, Kristin A MacDonald
1Departments of Surgical and Radiological Sciences, University of California-Davis, CA 95616, USA. kejandrey@ucdavis.edu
Veterinary Clinical Pathology
|December 6, 2008
Summary
Platelet Function Analyzer-100 (PFA-100) closure time (CT) did not significantly differ between healthy cats and those with hypertrophic cardiomyopathy (HCM). This study establishes a feline reference interval for CT, useful for future feline hypercoagulability research.
Area of Science:
- Veterinary Medicine
- Cardiology
- Hematology
Background:
- Hypercoagulability assessment in cats lacks simple analytical tools.
- The Platelet Function Analyzer-100 (PFA-100) measures platelet function via closure time (CT).
- Hypertrophic cardiomyopathy (HCM) in cats may be associated with hypercoagulability and thromboembolic events.
Purpose of the Study:
- Establish a feline reference interval for PFA-100 CT.
- Measure CT in cats with HCM.
- Compare CT between healthy cats and cats with HCM.
Main Methods:
- Analyzed citrated blood samples from 42 healthy cats and 30 cats with HCM.
- Measured CT in triplicate using the PFA-100 according to manufacturer specifications.
- Compared CT data using Student's t-test and ANOVA.
Main Results:
- Median CT for healthy cats was 64 seconds (range 43-176 seconds).
- Median CT for cats with HCM was 74 seconds (range 48-197 seconds).
- No significant difference in CT was found between healthy cats and cats with HCM, or among different HCM severity groups.
Conclusions:
- A feline reference interval for PFA-100 CT was established.
- Cats with HCM do not exhibit significantly shorter CTs compared to healthy cats.
- Findings suggest PFA-100 CT may not be a reliable indicator of hypercoagulability in feline HCM.
