Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haemophilia: Novel Therapies and Diagnostic Challenges.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2026
Same author

Expanding Horizons in Thrombosis and Hemostasis: From Molecular Determinants to Real-World and Expert Opinion Evidence.

Hamostaseologie·2026
Same author

Diagnosis and Management of Immune Platelet Transfusion Refractoriness.

Hamostaseologie·2026
Same author

Anti-HPA-1a IgG3 subclass antibodies induce strong platelet phagocytosis.

British journal of haematology·2026
Same author

From Case Reports to Cohort Studies: The Many Faces of Clinical Research in Thrombosis and Haemostasis.

Hamostaseologie·2026
Same author

Proof of concept for aqueous two-phase system-based extraction of cell-free DNA from plasma for liquid biopsy applications.

Scientific reports·2026

Related Experiment Video

Updated: Jun 27, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Transfusion-associated graft-versus-host disease.

Heiko Rühl1, Gregor Bein, Ulrich J H Sachs

  • 1Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany.

Transfusion Medicine Reviews
|December 6, 2008
PubMed
Summary

Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare but fatal blood transfusion complication. Identifying and preventing TA-GvHD in high-risk patients is crucial due to lack of effective treatments.

More Related Videos

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Related Experiment Videos

Last Updated: Jun 27, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Transfusion-associated graft-versus-host disease (TA-GvHD) is a severe, often fatal, complication of blood transfusions.
  • It occurs when transfused T lymphocytes attack the recipient's tissues due to immunodeficiency or HLA compatibility.
  • Effective treatments are lacking, emphasizing the need for risk identification and prevention strategies.

Purpose of the Study:

  • To review and identify established and potential risk factors for TA-GvHD.
  • To highlight patient groups requiring careful consideration for transfusion protocols.

Main Methods:

  • Literature review and synthesis of existing data on TA-GvHD risk factors.
  • Categorization of risk factors into definite, possible, and unproven.

Main Results:

  • Definite TA-GvHD risks include HLA-matched transfusions, transfusions from relatives, intrauterine/exchange transfusions, congenital immunodeficiencies, bone marrow/stem cell transplants, and lymphomas.
  • Patients with hematologic malignancies, solid tumors, or solid organ transplants are at possible risk and need further evaluation.
  • Increased risk in newborns and HIV/AIDS patients remains unproven.

Conclusions:

  • Risk stratification is essential for preventing TA-GvHD in vulnerable patient populations.
  • Specific transfusion strategies are necessary for patients with identified high-risk factors.
  • Further research may clarify risks in populations like newborns and HIV/AIDS patients.