Development of dose-volume relation model for gamma knife surgery of non-skull base intracranial meningiomas
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Published on: February 17, 2023
Hyun-Tai Chung1, Dong Gyu Kim, Sun Ha Paek
1Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Purpose:
To provide a dose-volume relationship for gamma knife surgery (GKS) of non-skull base intracranial meningiomas.
Methods And Materials:
The radiologic outcomes of GKS of 82 imaging-defined benign meningiomas located at non-skull base areas were analyzed. A total of 80 patients were included and all underwent treatment with GKS as the first and the only treatment modality. The mean patient age was 55.0 years (range, 26-78) and the mean tumor volume was 5.6 cm(3) (range, 0.5-16.8). On average, 14.6 Gy (range, 10-20) was applied to the 50% isodose surface. The binary logistic regression method was applied to find prognostic factors of signal change (SC) on T(2)-weighted magnetic resonance imaging after GKS.
Results:
The actuarial tumor control rate was 91.6% at 5 years. A total of 29 lesions (35.4%) showed newly developed or aggravated SCs. The volume irradiated >or=14 Gy was the only statistically significant (p < .01) prognostic factor of SC. A dose-volume relation model obtained from the cases without SC estimated a 12.2% SC probability.
Conclusion:
This model can be used in GKS to treat small- to medium-size (<9.2 cm(3)) non-skull base meningiomas.
