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Related Experiment Video

Updated: Jun 27, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Electrophysiological function during voiding after simulated childbirth injuries.

Hai-Hong Jiang¹, A Marcus Gustilo-Ashby, Levilester B Salcedo

¹Biomedical Engineering Department, Cleveland Clinic, 9500 Euclid Ave. ND20, Cleveland, OH 44195, USA.

Experimental Neurology

|December 6, 2008

Summary

This summary is machine-generated.

Dual injuries during vaginal delivery slow the recovery of the external urethral sphincter (EUS) and pudendal nerve function, potentially explaining long-term incontinence after childbirth.

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Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

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Last Updated: Jun 27, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

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Published on: August 28, 2020

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

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Published on: April 27, 2014

Area of Science:

Neuroscience
Urology
Obstetrics

Background:

Vaginal delivery can cause injuries to the pudendal nerve and external urethral sphincter (EUS).
These injuries are linked to stress urinary incontinence, but the impact of combined injuries on neuromuscular recovery is unclear.

Purpose of the Study:

To investigate the neuromuscular recovery of the micturition reflex after different types of vaginal delivery-related injuries.
To assess the effects of combined pudendal nerve crush (PNC) and vaginal distension (VD) on EUS electromyogram (EMG) and pudendal nerve motor branch potentials (PNMBP).

Main Methods:

Examined EUS EMG and PNMBP during voiding at 4 days, 3 weeks, and 6 weeks post-injury.
Injuries included VD, PNC, combined PNC+VD, and pudendal nerve transection (PNT) in a rat model.
Histological analysis of pudendal nerve and urethral specimens.

Main Results:

No EUS EMG bursting activity was observed 4 days after any injury or 3 weeks after PNC+VD.
Recovery of bursting activity was noted at 3 weeks (VD, PNC) and 6 weeks (PNC+VD), but intraburst frequency remained reduced.
PNMBP results mirrored EMG, with some exceptions showing increased frequency after PNC and PNC+VD.
PNT resulted in no recovery of EUS or pudendal nerve function by 6 weeks.

Conclusions:

Combined injuries (PNC+VD) lead to slower recovery of voiding bursting discharge compared to single injuries (PNC or VD).
Histological findings support the delayed functional recovery.
These findings may explain the persistent pudendal nerve dysfunction observed years after vaginal delivery.