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Anemia and risk of hospitalization in pediatric chronic kidney disease

Amy O Staples1, Craig S Wong, Jodi M Smith

  • 1Division of Pediatric Nephrology, University of New Mexico, Albuquerque, NM 87131, USA. astaples@salud.unm.edu

Clinical Journal of the American Society of Nephrology : CJASN
|December 6, 2008
PubMed

Insights

Anemia prevalence increases with chronic kidney disease (CKD) stage in children. Anemic children with predialysis CKD face a higher risk of hospitalization, underscoring the importance of monitoring anemia in this population.

Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Chronic Kidney Disease Research

Background:

  • Anemia is a known complication of chronic kidney disease (CKD).
  • The prevalence and impact of anemia across pediatric CKD stages remain unclear.
  • Understanding anemia's role in pediatric CKD morbidity is crucial.

Purpose of the Study:

  • To determine the prevalence of anemia in pediatric patients across different stages of chronic kidney disease (CKD).
  • To investigate the association between anemia and hospitalization risk in children with predialysis CKD.

Main Methods:

  • Analysis of 2,779 pediatric patients (ages 2+) with CKD stages II-V from the North American Pediatric Renal Trials and Collaborative Studies database.
  • Descriptive statistics and logistic regression modeling were used.
  • Anemia defined as hematocrit < 33%.

Main Results:

  • Anemia prevalence rose from 18.5% in CKD stage II to 68% in CKD stage V (predialysis).
  • Anemic children showed a 55% increased likelihood of hospitalization compared to non-anemic children (OR 1.55).
  • Similar associations were observed with hematocrit cutoffs of 36% and 39%.

Conclusions:

  • Anemia prevalence escalates with CKD stage in pediatric predialysis patients.
  • Anemia is significantly linked to increased hospitalization risk in this population.
  • Further research on anemia correction's impact on hospitalization is warranted.
Abstract

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