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Related Concept Videos

NMR Spectroscopy of Benzene Derivatives01:37

NMR Spectroscopy of Benzene Derivatives

Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling constants depend...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Structure of Benzene: Kekulé Model01:07

Structure of Benzene: Kekulé Model

In 1865, August Kekule suggested the structure of benzene according to the structural theory of organic chemistry based on the three assertions—formula of benzene is C6H6, all the hydrogens of benzene are equivalent, and each carbon must have four bonds due to its tetravalency.
He proposed that benzene has a cyclic structure of six carbon atoms attached to one hydrogen atom each, with three alternating pi bonds.
Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.

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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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N-Benzylformamide at 150 K.

Anna Michta1, Maria Nowak, Joachim Kusz

  • 1Institute of Chemistry, University of Silesia, Katowice, Poland. anna.michta@us.edu.pl

Acta Crystallographica. Section C, Crystal Structure Communications
|December 6, 2008
PubMed
Summary

This study details the crystal structure of a C(8)H(9)NO compound, revealing N-H...O hydrogen bonds forming chains and C-H...O bonds creating sheets. This compound is significant for biochemists due to its role in preventing alcohol-related metabolic toxicity.

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Area of Science:

  • Crystallography
  • Biochemistry
  • Organic Chemistry

Background:

  • The study investigates a specific organic compound with the molecular formula C(8)H(9)NO.
  • Understanding the crystal structure of such compounds is crucial for predicting their chemical and biological properties.

Purpose of the Study:

  • To determine and analyze the crystal structure of the title compound.
  • To compare experimental data with calculated values and related derivatives.
  • To explore the correlation between the IR spectrum and hydrogen bond energy.

Main Methods:

  • X-ray crystallography was used to determine the crystal structure.
  • Computational methods were employed for data comparison.
  • Infrared (IR) spectroscopy was utilized to analyze hydrogen bonding.

Main Results:

  • The compound crystallizes with Z'=2, featuring N-H...O hydrogen-bonded chains and C-H...O hydrogen bonds forming 2D sheets.
  • Molecules adopt trans and anti conformations, with the formamide group twisted out of the benzyl group plane.
  • A correlation between the IR spectrum and hydrogen bond energy was established.

Conclusions:

  • The crystal structure provides insights into intermolecular interactions and molecular conformation.
  • The compound's structure and properties are relevant to its preventative function against toxic alcohol metabolites.
  • This research contributes to understanding molecular systems with potential biochemical applications.