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Septo-optic dysplasia and psychiatric disorders: a case report
Paola Bini1, Lorenza Montalbetti, Pietro Tosca
1Department of Behavioural Neurology, UCADH, Institute of Neurology IRCCS C. Mondino, University of Pavia, Italy. paola.bini@mondino.it
Background:
Septo-optic dysplasia, a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome in which the midline defects may be implicated in psychiatric disturbances.
Objective:
To describe a case of septo-optic dysplasia associated with depression and psychosis and to discuss the role of these developmental abnormalities in psychiatric disturbances.
Methods:
The patient's clinico-anamnestic, neuroradiologic, neuropsychiatric, endocrinologic, ophthalmologic, and genetic profile was evaluated.
Conclusions:
Developmental abnormalities due to disruption of the complex neural network linking the septum pellucidum with other limbic structures may have been involved in the affective and psychotic disturbances observed in our patient.
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