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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Cell Diversity01:13

Cell Diversity

The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
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Glial Cells

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Related Experiment Video

Updated: Jun 27, 2026

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
10:05

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

Giant cell formation and function.

William G Brodbeck1, James M Anderson

  • 1Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.

Current Opinion in Hematology
|December 6, 2008
PubMed
Summary
This summary is machine-generated.

New research identifies common molecular factors like vitronectin and specific receptors involved in multinucleated giant cell formation. These findings offer potential therapeutic targets for inhibiting giant cell activity.

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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Published on: October 21, 2014

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • Multinucleated giant cells (MGCs) play critical roles in various physiological and pathological processes.
  • Understanding the molecular and cellular mechanisms of MGC formation and function is crucial for developing targeted therapies.

Purpose of the Study:

  • To review and synthesize current knowledge on the molecular and cellular mechanisms of multinucleated giant cell formation and function.
  • To identify common factors and pathways involved across different MGC types.

Main Methods:

  • Literature review of recent studies focusing on osteoclasts and foreign body giant cells.
  • Analysis of identified adhesion proteins, fusion factors, and receptors involved in MGC biology.

Main Results:

  • Common factors contributing to MGC formation and function include vitronectin, dendritic cell-specific transmembrane protein, and macrophage fusion receptor.
  • Adhesion and fusion mechanisms are complex and influenced by diverse species, models, and cell types studied.

Conclusions:

  • Recently identified factors, along with the osteoclast receptor alphavbeta3, represent potential therapeutic targets for modulating MGC formation and function.
  • Further research into intracellular and intercellular signaling pathways is essential for a comprehensive understanding and therapeutic development.