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Updated: Jun 27, 2026

Protocol for Isolating the Mouse Circle of Willis
Published on: October 22, 2016
Thomas Willis of the "circle of Willis"
Kishor A Choudhari1, Divyesh Sharma, Joe J Leyon
1Department of Neurosurgery, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom. kchoudhari@hotmail.com
Abstract:
Thomas Willis is best known for the circle of Willis. The life story of this 17th- century medical genius, who remains an inspiration for all neuroscientists 300 years later, is summarized in this article. We outline his academic achievements, including his description of the famous basal arterial circle, and we attempt to obtain insight into his visionary thought process through this historical review.
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