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Intranuclear inclusion bodies in recurrent aphthous ulcers with a herpetiform pattern
Oral Surgery, Oral Medicine, and Oral Pathology
|March 1, 1977
Summary
Intranuclear bodies in recurrent aphthous ulcers are not viral. These spherical, granular, and filamentous structures likely indicate altered cellular metabolism from various causes.
Area of Science:
- Cellular Biology
- Oral Pathology
Background:
- Recurrent aphthous ulcers (RAUs) with a herpetiform pattern can exhibit unusual cellular changes.
- Previous hypotheses suggested viral etiology for intranuclear inclusions in RAUs.
Purpose of the Study:
- To characterize the nature of intranuclear bodies observed in the epithelial cells of RAUs.
- To investigate the potential cause of these intranuclear bodies.
Main Methods:
- Microscopic examination of epithelial cells from RAUs.
- Analysis of intranuclear bodies for the presence of DNA and RNA.
Main Results:
- Spherical, granular, and filamentous intranuclear bodies (0.8-1.2 µm) were identified in marginal epithelial cells.
- These bodies lacked detectable DNA or RNA, ruling out a viral origin.
- One to four bodies were observed per nucleus.
Conclusions:
- The intranuclear bodies are unlikely to be viral.
- It is hypothesized that these inclusions represent a common manifestation of altered cellular metabolism.
- Multiple etiologic factors may contribute to the observed cellular changes in RAUs.