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Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

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Published on: May 21, 2018

Intracellular and extracellular serpins modulate lung disease.

D J Askew¹, G A Silverman

¹UPMC Newborn Medicine Program, Children's Hospital of Pittsburgh and Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. rsidja@mwri.magee.edu

Journal of Perinatology : Official Journal of the California Perinatal Association

|December 17, 2008

Summary

Pulmonary diseases arise from an imbalance between peptidases and their inhibitors. This review focuses on serine peptidase inhibitors (serpins), their lung function, and therapeutic potential.

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

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Area of Science:

Pulmonary Medicine
Biochemistry
Molecular Biology

Background:

An imbalance between peptidases and their inhibitors is linked to pulmonary diseases in adults and neonates.
Serine peptidase inhibitors (serpins) are the primary source of antipeptidase activity in the lung.

Purpose of the Study:

To review the mechanism of serpin inhibition.
To elucidate the roles of serpins in normal and pathological lung conditions.
To explore the therapeutic potential of serpins in treating lung diseases.

Main Methods:

Literature review of serpin function and inhibition mechanisms.
Analysis of serpin roles in various lung pathologies.
Evaluation of serpins as therapeutic targets.

Main Results:

Serpins employ a specific mechanism to inhibit serine peptidases.
Dysregulation of serpins contributes to the pathogenesis of several lung diseases.
Serpins show promise as agents for treating pulmonary conditions.

Conclusions:

Understanding serpin mechanisms is crucial for addressing peptidase-inhibitor imbalances in lung disease.
Serpins represent a significant area for therapeutic development in respiratory medicine.