Related Experiment Video
Updated: Jun 27, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
Corticosteroid induced psychosis in the pain management setting
Ramsin M Benyamin1, Ricardo Vallejo, Jeffery Kramer
1Millennium Pain Center, Bloomington, IL 61701, USA. benyamin@millenniumpaincenter.com
Background:
Synthetic corticosteroids are commonly utilized in interventional pain management procedures. These substances have potential side-effects including psychological adverse events.
Objective:
We describe a case of substance-induced psychotic disorder resulting from corticosteroids administration.
Design:
Case Report.
Methods:
We describe a 67-year-old male that, six months prior to being consulted at our center, received a cervical epidural, 4 level medial branch blocks, 4 trigger point injections and a tendon injection in the shoulder all including corticosteroids all in one treatment session.
Results:
Approximately 7 days following the multiple injections, the patient developed psychotic episodes including racing thoughts, anger, agitation, pressured hyperverbal speech and paranoia. The symptoms spontaneously resolved in approximately 7-10 days.
Discussion:
Although well known as a potential complication, corticosteroid induced psychosis secondary to interventional pain procedures have never been reported. We further discuss this potential side effect of utilizing corticosteroids and emphasize the need for guidelines regarding steroid utilization.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Analgesia and Pain Management
Cushing Syndrome II: Pathophysiology
Cushing Syndrome I: Introduction