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Differential effects of chronic ethanol consumptions or thiamine deficiency on spatial working memory in Balb/c mice:
A Tako1, D Beracochea, L Lescaudron
1Université d' Abidjan, Ivory Coast.
Abstract:
This study was aimed to compare the effects of either a thiamine deficiency or a chronic ethanol consumption on memory and on neuronal density within the median mammillary nucleus. Results showed that alcohol-treated (48 weeks) mice exhibited a behavioral impairment in a sequential alternation task characterized by a progressive decay of alternation rates as a function of the number of trials; such a deficit was not observed in controls and thiamine-deficient subjects. A quantitative analysis using histological sections showed an important reduction of neuronal density within the mammillary bodies following the alcohol treatment but not following thiamine deficiency.